I'm having the same problem at the moment too.

I believe it might have been caused by me equipping a power axe before heading into battle. CTD occurred when loading the level and now whenever i get to the login attempt after launching the game. To me that indicates a possible problem with loading something to do with the character. 

I got up to a mission load screen ( plasma gun and sword equipped for the first time)
Crashed when loading - now the game wont load out of steam without crashing. 

Any changes happen in the last 12 hours to the game/steam? 

Went to start the mission, black screen and crash.

Now will only load the splash screen and 3 seconds of audio before black screen crash.

Validated files, and nothing, checked the D3Dcompiler_47 was present and still no go.

Same here.

Last night, I had an odd situation where the vendor kept telling me I didn't have enough gold for purchases that I did. When I played, half of the gear on my guy had vanished. That in addition to the inventory screen showing up behind the icons that were supposed to be above it and duplicate items appearing with every addition to my inventory.

Now I cannot get into the game at all. I have tried all of the various fixes posted here. Nothing.

Had the same thing happen. Almost got to try the game. I bought the green plasma gun from the vendor, went to start a mission and the game crashed and now just dies on the login screen.

Does the dev team need debug logs or anything of the such as well?

completed two missions before. nice game:)

Windows 10 64-Bit

AMD A-10 Processor

AMD R9 380X

16GB RAM

Running from 1TB 2.5" 7200RPM drive