I get a hardlock when playing with the Heavy Weapons Inquisitor using the Heavy Bolter. I typically get about 4-5 minutes in and then the game will hardlock whilst firing my heaver bolter into enemy Chaos Cultists (using the right-mouse button attack).
Operating System: Windows 10 Pro 64-bit
Memory: 16384MB RAM
Card name: NVIDIA GeForce GTX 970
Happy to provide a full DXDiag should it help.