One player reported that he experienced very often crash when farming the boss great unclean one (chap 5)
Steam account: sanguinum000
According to him, when the boss dies and items begin to drop, there is high chance that the game would crash.
He has tried reinstalling the game or change video settings with no improvement.
Similar issues have been reported before:
Sometimes the issue would mysteriously vanish but for some unfortunate guys the issue would always be there.
If further information is needed (like his hardware) please let me know :)