I've crashed to desktop several times. Usually it seems to happen at random, it seems especially common in multiplayer. The one time it seemed to be caused by something specific was respawning after a death in multiplayer. On the outdoor map mobs in certain positions can't be shot with a heavy bolter. The shots just go right through them. You either have to kill them with grenades or get them to move. I somehow managed to blow holes in the ground that you could see the water through. That also happened with the same heavy bolter. Once while trying to join a tarot mission with another person the loading bar got stuck. Here's my system specs.
OS: Windows 10
RAM: 16gb Corsair Vengeance Pro
GPU: GTX 980ti