The Khorne hunt final mission (straight up on the ivory path) is consistently disabling the effects of all my gear on my crusader leaving me with little to no damage or defence.

I have to remove and re-equip all the gear to get the stats back.  Luckily for me, this then made the mission playable.

This was a very unpleasant surprise, especially since this was the void crusade finale and failing would have made the whole crusade worthless.