For whatever reason 50% of the time the autoaim with controller favors enemies in the back or far off, instead of some directly in front or close by, resulting in a hilarious dance act, where you have to try get it to target more appropriate "nearby" targets, by rotating the camera, moving around.
I suspect some strange screen/camera space projection tracing into worldspace is happening here, which does not work very well in a isometric arpg as target selection.
In a similar note, its often really frustrating to target a boss inside his henchmen and also stay on the target.
I guess some extra targeting options could help here, like "target nearest first", "target nearest boss first" or "target highest damage". Could be just a sort-able list as advanced option.